Welcome to Dr. Fridman's Lab

Our research group has been interested in the mode of action studies of various antimicrobial, and antitumor agents.

In the case of antimicrobial agents, we are currently focused on drugs that target the bacterial ribosome, including the A-site binding antibiotics such as aminoglycosides, and P-site binding antibiotics such as lincosamides and chloramphenicol. We use these molecules to study various bacterial antibiotics resistance mechanisms and explore new chemical strategies to overcome these mechanisms.

In the case of antitumor agents, we are focused on the potent chemotherapeutic agents: anthracyclines. We design and synthesize anthracycline analogues and use these compounds to study their anti-proliferative activity of these important drugs and the mechanisms that lead to their undesired and problematic toxic side effects on a molecular level.

Our studies are highly interdisciplinary and incorporate synthetic organic chemistry with methodologies from the fields of microbiology, cell biology, and microscopy.

Contact Details:

Dr. Micha Fridman

School of Chemistry,
Raymond and Beverly Sackler Faculty of Exact Sciences,
Tel Aviv University,Ramat Aviv, Tel Aviv, Israel 69978

Email: mfridman@post.tau.ac.il
Phone: 972-3-640-8687
Fax: 972-3-640-9293 Lab Phone: 972-3-640-5647